Please take a minute to find your feet and settle in with the Plesk panel.
1. Once logged into the host panel, navigate to WEBSITE & DOMAINS
2. Select HOSTING & DNS and click HOSTING SETTINGS
3. Scroll down to WEB SCRIPTING AND STATICS and DISABLE “Microsoft ASP.NET support version 4.7.2”
You have successfully enable support for .NET Core (all versions) and .NET 5 and higher.
Extra information regarding this: .NET core and .NET 5 does not make use of the ASP.NET runtime above. (No managed code), so by disabling it, it will allow .NET core and .Net 5 plus deployments to run correctly.
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